Jordan’s solar tender bears fruitInterest in the MENA country’s burgeoning solar PV sector attracts Japanese finance as modest plans unveiled. February 2, 2015 Ilias Tsagas Installations Markets Markets & Policy Utility Scale PV Jordan Middle East A PV plant build by Alcazar Energy in Jordan.Image: Alcazar EnergyShare Qatars Nebras Power, alongside partners Diamond Generating Europe (a wholly owned subsidiary of Mitsubishi Corporation) and KAWAR Group, a Jordanian company, have signed a finance agreement for Jordans 52.5 MW solar PV Shams Maan power plant.The finance agreement is for 18 years and Nebras Power will own 35% of the project, Diamond Generating Europe 35% and Kawar Group 30%.Present at the signing, which took place on January 18 at the prime ministry building in Jordans capital Amman, was Japans newly re-elected prime minister Shinzo Abe.The financing of the project has been jointly overseen by a group of international banks and export credit agencies, including Japan for International Cooperation (JBIC), Nippon Export and Investment Insurance (NEXI), Mizuho Bank and Standard Charter Bank.Commenting on the signing, Nebras Powers chairman Fahad Hamad Al-Mohannadi said: “Nebras Power continues with its commitment to expand internationally in a conservative manner while sticking to its core areas of expertise. The importance of this project comes from being the first project and investment for Nebras Power and it is a confirmation of the companys policy of diversifying the fuel in its future investments.”Khalid M. Jolo, CEO of Nebras Power, added: “Nebras Power will strongly focus on building its portfolio in a balanced manner, which will include renewables.” The 52.5 MW PV plant The Shams Maan PV plant will be financed, owned and operated by Nebras Power, along with its partners.Popular content The Hydrogen Stream: 20 MW green hydrogen plant in Finland, two Australian projects move forward Sergio Matalucci 20 April 2021 pv-magazine.com Storegga, Shell and Harbour Energy want to set up a 20 MW blue hydrogen production facility in the U.K. Australia’s Origin Energy wants to build a hy… Enabling aluminum in batteries Mark Hutchins 27 April 2021 pv-magazine.com Scientists in South Korea and the UK demonstrated a new cathode material for an aluminum-ion battery, which achieved impressive results in both speci… ITRPV: Large formats are here to stay Mark Hutchins 29 April 2021 pv-magazine.com The 2021 edition of the International Technology Roadmap for Photovoltaics (ITRPV) was published today by German engineering association VDMA. The re… Solar park built on rough wooden structures comes online in France Gwénaëlle Deboutte 26 April 2021 pv-magazine.com French company Céléwatt energized its 250 kW ground-mounted array, built with mounting structures made of raw oak wood.April 26, 2021 Gwénaëlle Debo… Spanish developer plans 1 GW solar plant coupled to 80 MW of storage, 100 MW electrolyzer Pilar Sánchez Molina 22 April 2021 pv-magazine.com Soto Solar has submitted the project proposal to the Ecological Transition and the Demographic Challenge (Miteco). The solar plant could start produc… We all trust the PV performance ratio test Dario Brivio, Partner 20 April 2021 pv-magazine.com The performance ratio test is at the core of the handover from EPC to owner. Yet sometimes, even when best practice is applied – and without particul… The Hydrogen Stream: 20 MW green hydrogen plant in Finland, two Australian projects move forward Sergio Matalucci 20 April 2021 pv-magazine.com Storegga, Shell and Harbour Energy want to set up a 20 MW blue hydrogen production facility in the U.K. Australia’s Origin Energy wants to build a hy… Enabling aluminum in batteries Mark Hutchins 27 April 2021 pv-magazine.com Scientists in South Korea and the UK demonstrated a new cathode material for an aluminum-ion battery, which achieved impressive results in both speci… ITRPV: Large formats are here to stay Mark Hutchins 29 April 2021 pv-magazine.com The 2021 edition of the International Technology Roadmap for Photovoltaics (ITRPV) was published today by German engineering association VDMA. The re… Solar park built on rough wooden structures comes online in France Gwénaëlle Deboutte 26 April 2021 pv-magazine.com French company Céléwatt energized its 250 kW ground-mounted array, built with mounting structures made of raw oak wood.April 26, 2021 Gwénaëlle Debo… Spanish developer plans 1 GW solar plant coupled to 80 MW of storage, 100 MW electrolyzer Pilar Sánchez Molina 22 April 2021 pv-magazine.com Soto Solar has submitted the project proposal to the Ecological Transition and the Demographic Challenge (Miteco). The solar plant could start produc… We all trust the PV performance ratio test Dario Brivio, Partner 20 April 2021 pv-magazine.com The performance ratio test is at the core of the handover from EPC to owner. Yet sometimes, even when best practice is applied – and without particul… The Hydrogen Stream: 20 MW green hydrogen plant in Finland, two Australian projects move forward Sergio Matalucci 20 April 2021 pv-magazine.com Storegga, Shell and Harbour Energy want to set up a 20 MW blue hydrogen production facility in the U.K. Australia’s Origin Energy wants to build a hy… 123456Share Ilias Tsagas Greek-born Ilias has written for pv magazine since 2012, reporting on renewable energy news, electricity market developments and energy policy. His geographic area of expertise includes Europe and the MENA region.More articles from Ilias Tsagas [email protected] Related content Higher performance with bigger modules a ‘no brainer’ Sandra Enkhardt 26 April 2021 pv-magazine.com Jan Bicker, who replaced Steve O’Neil as the CEO of REC on March 1, says that one of his top priorities is the ongoing d… Solar and wind could provide half of 2040 power mix across 22 African nations Max Hall 29 April 2021 pv-magazine.com The International Renewable Energy Agency has combined energy infrastructure commitments across a huge swathe of the con… Auctions will not influence PPA prices in Spain Pilar Sánchez Molina 20 April 2021 pv-magazine.com LevelTen Energy reports each quarter on the prices that wind and solar project developers have offered for power purchas… African solar installers feel the pinch of rising panel prices Max Hall 26 April 2021 pv-magazine.com With Chinese manufacturers having warned they will pass on escalating component costs, and shipping expenses soaring sin… Lack of policy hampers energy storage in Cyprus Ilias Tsagas 29 April 2021 pv-magazine.com Although the government last month started offering purchase incentives for residential batteries, a net metering regime… The Hydrogen Stream: Offshore hydrogen pipeline and more electrolysis capacity in Germany Sergio Matalucci 27 April 2021 pv-magazine.com Big German conglomerates such as Siemens, RWE and Vattenfall keep pushing for green hydrogen development through different projects. iAbout these recommendations Elsewhere on pv magazine… MIBEL alcanzó nuevamente los precios más bajos de Europa mientras subieron en el resto de mercados eléctricos pv magazine 23 March 2021 pv-magazine.es En la tercera semana de marzo los precios de la mayoría de mercados eléctricos europeos subieron, mientras que MIBEL mar… Tasmanian Labor installs solar at the top of its campaign promises Blake Matich 8 April 2021 pv-magazine-australia.com Tasmania (TAS) is going to the polls on May 1, and the opposition Labor Party has put forth a $20 million plan to fund l… India closing in on 7 GW of rooftop solar pv magazine 13 April 2021 pv-magazine-australia.com India’s cumulative installed capacity of rooftop solar stood at 6,792 MW as of December 31, 2020, with 1,352 MW having b… Spotlight on Australian solar Bella Peacock 21 April 2021 pv-magazine-australia.com Calculating the average sunlight hours data from the Bureau of Meteorology from January toDecember 2020, Darwin was cro… Q&A: EEW’s $500 million Gladstone solar to hydrogen project is just the start Blake Matich 18 March 2021 pv-magazine-australia.com pv magazine Australia: Australia is the testing ground for a lot of different aspects of the future green hydrogen market. Cracking the case for solid state batteries pv magazine 29 April 2021 pv-magazine-australia.com Scientists in the UK used the latest imaging techniques to visualize and understand the process of dendrite formation an… iAbout these recommendations 1 comment Pingback: Jordanian largest PV power plant ready for commissioning – oranITLeave a Reply Cancel replyPlease be mindful of our community standards.Your email address will not be published. Required fields are marked *CommentName * Email * Website Save my name, email, and website in this browser for the next time I comment. By submitting this form you agree to pv magazine using your data for the purposes of publishing your comment.Your personal data will only be disclosed or otherwise transmitted to third parties for the purposes of spam filtering or if this is necessary for technical maintenance of the website. Any other transfer to third parties will not take place unless this is justified on the basis of applicable data protection regulations or if pv magazine is legally obliged to do so.You may revoke this consent at any time with effect for the future, in which case your personal data will be deleted immediately. Otherwise, your data will be deleted if pv magazine has processed your request or the purpose of data storage is fulfilled.Further information on data privacy can be found in our Data Protection Policy.iAbout these recommendationsKeep up to date pv magazine Global offers daily updates of the latest photovoltaics news. We also offer comprehensive global coverage of the most important solar markets worldwide. Select one or more editions for targeted, up to date information delivered straight to your inbox.Email* Select Edition(s)*Hold Ctrl or Cmd to select multiple editions.Tap to select multiple editions.Global (English, daily)Germany (German, daily)U.S. (English, daily)Australia (English, daily)China (Chinese, weekly)India (English, daily)Latin America (Spanish, daily)Brazil (Portuguese, weekly)Mexico (Spanish, daily)Spain (Spanish, daily)France (French, daily)We send newsletters with the approximate frequency outlined for each edition above, with occasional additional notifications about events and webinars. We measure how often our emails are opened, and which links our readers click. To provide a secure and reliable service, we send our email with MailChimp, which means we store email addresses and analytical data on their servers. You can opt out of our newsletters at any time by clicking the unsubscribe link in the footer of every mail. For more information please see our Data Protection Policy. Subscribe to our global magazine SubscribeOur events and webinars Out with the old… A guide to successful inverter replacement , pv-magazine.com Discussion participantsRoberto Arana-Gonzalez, Service Sales Manager EMEA, SungrowFranco Marino, Regional Service Mana… Grid code compliance in megawatt projects 27 April 2021 pv-magazine.com Discussion participantsEhsan Nadeem Khan, Grid Code Compliance Engineer, meteocontrolModeratorsMarian Willuhn, Editor… Virtual Roundtables USA 17 November 2020 pv-magazine.com We will be hosting the second edition of our successful Virtual Roundtables this year in November. The program will be f… iAbout these recommendations pv magazine print Flexible tools for the next generation Jonathan Gifford 7 April 2021 pv-magazine.com A solar manufacturing investment cycle appears to be underway in Europe, with equipment suppliers reporting surging leve… ESG criteria: Should developers take notice? Michael Fuhs 7 April 2021 pv-magazine.com Something is brewing in the financial world. “Sustainable finance” and the growth of ESG funds have been taking the mark… The ideal format pv magazine 7 April 2021 pv-magazine.com The speed at which manufacturers are introducing changes from one product generation to the next is accelerating – curre… Time to standardize pv magazine 7 April 2021 pv-magazine.com Not all quality control plans, processes and agreements are created equal, writes Frédéric Dross, the VP of strategic de… Korea shifts into top gear pv magazine 7 April 2021 pv-magazine.com There is a fresh sense of urgency and common purpose in South Korea toward combating climate change. In 2021, government… China’s push for decarbonization Andreas Walstad 7 April 2021 pv-magazine.com The carbon market is finally a reality in China. After 10 years of delays, regional pilot schemes and general uncertaint… iAbout these recommendations
Most of the breakthrough discoveries and remarkable inventions throughout history have something in common: They are the result of curiosity. Without curiosity, Sir Isaac Newton would have never formulated the laws of physics, Alexander Fleming probably wouldn’t have discovered penicillin, and Marie Curie’s pioneering research on radioactivity may not exist. The impulse to seek new information and experiences and explore novel possibilities is a basic human attribute. Curiosity is the desire to learn and explore new things, and find out how they work. The more curious we are about a topic, the easier it is to learn information about that topic.Curious people always ask questions and search for answers in their minds. Their minds are always active. Since the mind is like a muscle which becomes stronger through continual exercise, the mental exercise caused by curiosity makes our mind stronger and stronger.When we are curious about something, our mind expects and anticipates new ideas related to it. When the ideas come they will soon be recognised. Without curiosity, the ideas may pass right in front of us and yet we miss them because our mind is not prepared to recognise them.By being curious we will be able to see new worlds and possibilities which are normally not visible. They are hidden behind the surface of normal life, and it takes a curious mind to look beneath the surface and discover these new worlds and possibilities.Recently, researchers from the University of California, Davis conducted a series of experiments to discover what exactly goes on in the brain when our curiosity is aroused. These experiments revealed insights into how a form of intrinsic motivation – curiosity – affects memory. The team discovered that when curiosity motivated learning, there was increased activity in the hippocampus, a brain region that is important for forming new memories.“Curiosity may put the brain in a state that allows it to learn and retain any kind of information, like a vortex that sucks in what you are motivated to learn, and also everything around it,” explains lead author Dr Matthias Gruber.When our curiosity is triggered, we think more deeply and rationally about decisions and come up with more creative solutions. Experts say that stimulating curiosity is really important across all ages, from schools to the workplace and to elderly care. Learning or doing something new and different has been proven to enable positive attitude and happiness.Curiosity is an important trait of a genius. I don’t think we can find an intellectual giant who is not a curious person. Albert Einstein, Physicist and Nobel Laureate has been widely quoted as saying, “The important thing is not to stop questioning. Curiosity has its own reason for existing. Never lose a holy curiosity.”
narvikk/iStockBy MEREDITH DELISO, ABC News(NEW YORK) — About 1 in 4 New Yorkers has received at least one dose of COVID-19 vaccine, according to state data.Nearly 7.5 million total doses, including more than 1 million over the past seven days, have been administered statewide, officials said Saturday. While over 5 million New Yorkers — 25.3% of the state population — have so far received at least one dose, 13% are fully vaccinated.Nationwide, 23.3% of Americans have received at least one dose and 12.6% were fully vaccinated as of Friday, according to the Centers for Disease Control and Prevention.Those eligible to receive a COVID-19 vaccine in New York include people age 60 and older, health care personnel, long-term care facility residents and staff, first responders, teachers and child care workers, public transit workers, grocery store and restaurant workers, people with certain underlying health conditions and, most recently, public-facing public employees.In a statement, Gov. Andrew Cuomo said New York is “continuing our outreach across the state to address hesitancy and accessibility so that we can continue getting shots into people’s arms as quickly as possible.”“In the meantime,” he added, “it is essential that we continue to exercise basic safety protocols so we can continue to build on all the progress we’ve made on vaccinations.”The push for vaccinations comes as a new COVID-19 variant has been spreading in and around New York City.As of March 10, the New York variant represented about 39% of all samples sequenced in the most recent week, up from 31% the week before, suggesting it’s “a more infectious variant,” New York City Health Commissioner Dr. Dave Chokshi said at the time.The New York variant does not appear to cause more serious illness or reduce the effectiveness of vaccines, according to preliminary analysis, health officials said.ABC News’ Joshua Hoyos and Emily Shapiro contributed to this report.Copyright © 2021, ABC Audio. All rights reserved.
Established as a leading international trade fair for the bus and coach industry in 2018, Euro Bus Expo returns on 30 October – 1 November 2018, at the National Exhibition Centre (NEC), Birmingham.Visitor registration for the free-to-attend event is now open at www.eurobusxpo.comThe three-day biennial free-to-attend bus, coach and minibus trade show is Europe’s biggest in 2018.The show organisers are expecting to welcome over 9,000 industry buyers and decision makers from across Europe.Already, eight months out from the show open date, 91% of exhibition space has been sold, with almost 300 exhibitors expected.Many are planning to use the show to publicly launch their new products.Alongside the exhibition, a full seminar programme in the Master Class Theatre will be a major draw, with top speakers.Major vehicle manufacturers and dealers already booked include: Alexander Dennis Limited (ADL), BASE, Connaught, EVM, EvoBus, Isuzu, Irizar, MAN, Minis to Midis, Moseley, Optare, Scania, Temsa, Unvi, Van Hool, VDL, Volvo, Wrights Group and Yutong.Among the companies exhibiting at Euro Bus Expo for the first time are: Ceramex, Five Bars Mobile, Henkel, Herbert Kneitz/ Boyriven, Reacton Fire Suppression, Streamax Technology, The Tyre Equipment Company, Travel by Knight, Ultrafabrics Europe and Viriciti. Exhibitors in the Technology Zone will showcase the latest software solutions, the latest IT equipment, mobile technology, onboard wi-Fi, ticketing systems, revenue collection services.The Master Class Theatre will return again with seminars and keynotes from leading industry figures where you will gain in-depth knowledge on the latest hot topics.The miniplus Area, hosted by leading trade title miniplus, is dedicated solely to operators of small- and medium-sized passenger carrying vehicles.It will bring together exhibitors in the small vehicle sector to demonstrate the latest equipment and supplies available in this growing sector of the market.Suppliers will display purpose-built vehicles fitted with modern accessible aids including step-free design, wheelchair lifts, seats and other safety items, along with showcasing conversion services for those buyers with bespoke requirements.Britain’s coach and bus trade body, the Confederation of Passenger Transport UK (CPT) is once again the show partner.Says Event Director Helen Conway: “Euro Bus Expo 2018 is off to a flying start and the show is on track to sell-out well before the autumn.“We’ve received tremendous support from across the industry and it’s clear that Euro Bus Expo is seen as a key event for 2018.“Along with CPT we remain committed to delivering a quality show over three days which our audience can be proud of.” The show is co-located alongside the UK’s largest coach, bus, and minibus operator excellence awards.The prestigious black-tie routeone Awards takes place, welcoming 800 guests, in the evening of 31 October at the Hilton Birmingham Metropole’s banqueting suite, on the NEC site.Further information:Visit: Show website – www.eurobusxpo.comrouteone Awards website – www.routeoneawards.com
Facebook Pinterest Twitter Google+ WhatsApp IndianaLocalNewsSports Pinterest Twitter Google+ Previous articleBig Indiana teachers rally prompting many school closings on Nov. 19Next articleVeterans Day: facts and perks Associated PressNews from the Associated Press and its network of reporters and publications. Notre Dame wide receiver Chase Claypool (83) catches a pass while Duke cornerback Leonard Johnson (33) defends during the first half of an NCAA college football game in Durham, N.C., Saturday, Nov. 9, 2019. (AP Photo/Gerry Broome) DURHAM, N.C. (AP) — Ian Book trusted his legs to pick up chunks of yardage for No. 15 Notre Dame. The touchdowns came from his arm.Book rushed for a career-best 139 yards and threw four touchdown passes and the Fighting Irish routed Duke 38-7 on Saturday night.Book finished 18 of 32 for 181 yards passing, Chris Finke caught touchdown passes of 18 and 6 yards, and Chase Claypool and George Takacs also had short scoring catches.C’Bo Flemister rushed 2 yards for a TD for the Fighting Irish (7-2, No. 15 CFP). In winning their second straight and fifth in six games, they rolled up 469 total yards, led 21-0 before the Blue Devils picked up their second first down and kept them at bay the rest of the way.“It’s hard to win in November,” Book said. “You want to win every single game in November. It’s huge. … We’re still playing for a lot of things here.”Book became the first Notre Dame quarterback with 100 yards both rushing and passing since Brandon Wimbush did it two years ago against Wake Forest.“He’s just a heck of a football player,” Duke coach David Cutcliffe said.Book has accounted for seven touchdowns in his last two games, both victories over Atlantic Coast Conference schools. He threw for two TDs last week against Virginia Tech, then rushed for the winning score with 29 seconds left to beat the Hokies.The Blue Devils kept him from crossing the goal line in this one, prompting Book to quip that “I need to get faster.“I need to get in the end zone,” he said. “I’m kind of upset about it. But fast DBs, they caught me. … I was able to get the first downs … but I want to get in the end zone.”Quentin Harris was 16 of 28 for 102 yards for Duke (4-5) with a 29-yard touchdown pass to Aaron Young late in the second quarter. The Blue Devils have lost three straight and four of five since starting 3-1.THE TAKEAWAYNotre Dame: The Fighting Irish rushed for 288 yards — their best game on the ground in a month — against a decent Duke run defense, and 148 of those yards came on three carries, runs of 45 and 53 yards by Book and a 40-yarder by Jahmir Smith. Both co-starters — Tony Jones Jr. and Jafar Armstrong — were back, but they combined for just 27 yards on 10 attempts.Duke: The Blue Devils have played three 2018 College Football Playoff programs in 12 months — Clemson last November, and Alabama and now Notre Dame this season — and lost them all by a combined 108-16, failing to reach double-figure scoring in any of them. This loss puts Duke in bowl jeopardy: The Blue Devils must win two of their final three — against Syracuse, No. 22 Wake Forest and resurgent Miami — to reach their third straight bowl game.“I’m concerned with where we are with a rhythm” on offense, Cutcliffe said. “We’ve got an approach where we’re going to work like we’ve always worked, but I think a study of what we’re doing right now is real important. … You don’t panic. … We’ve got three big football games in front of us that we can go win.”POLL IMPLICATIONSWhile the Irish certainly have a case to climb a bit higher in the polls, it could work against them that the teams ranked alongside them in the mid-teens lost this week.BOOKING ITBook had 86 yards rushing by halftime, surpassing his previous single-game best of 81 set in the opener at Louisville. He gained more yards on one rush — covering 45 yards in the second quarter — than the Blue Devils’ entire offense had to that point (36), then went for 53 yards in the first minute of the fourth quarter that set up Jonathan Doerer’s 43-yard field goal.TURNING POINTDuke missed on a couple of chances to make it a one-score game, first squandering Shaka Heyward’s interception of Book’s pass late in the second quarter when the drive stalled at the Irish 26 and AJ Reed pushed a 44-yard kick wide right. Then, the Blue Devils’ first drive of the second half ended when Troy Pride Jr. intercepted Harris’ pass for Scott Bracey and Notre Dame turned that takeaway into Book’s second scoring pass to Finck.UP NEXTNotre Dame: Plays host to No. 25 Navy on Saturday. WhatsApp Facebook Book throws 4 touchdowns as Notre Dame defeats Duke By Associated Press – November 10, 2019 0 356
McConalogue twice tested negative last week before and after he attended a two-day meeting of the EU’s Agriculture and Fisheries Council in Brussels. But he tested positive after taking a post-Cabinet test Tuesday. It’s the first positive coronavirus test recorded by a member of the Irish government. The country’s 160-member lower house of parliament has been meeting since July in the 3,000-seat Dublin Convention Centre to ensure sufficient physical distancing. Besides McConalogue, the only other member to have been confirmed as contracting COVID-19 is Mary Lou McDonald, leader of the main opposition Sinn Féin party, who was stricken during the early weeks of the pandemic but recovered in April.Tuesday’s Cabinet meeting approved an accelerated return to a national lockdown, starting on Christmas Eve when all hospitality and personal services firms, such as restaurants and hairdressers, must shut by 3 p.m. It will be Ireland’s third national lockdown and comes just three weeks after the previous restrictions were eased.Family gatherings that had been approved to run until the first week of January now must end on the day after Christmas, called St. Stephen’s Day in Ireland.Deputy Prime Minister Leo Varadkar, who is among those being tested Wednesday, says restaurants and other social venues may not be allowed to reopen until March, depending on how quickly Ireland is able to source and deliver coronavirus vaccines. DUBLIN — Ireland’s government has been hit by its first confirmed COVID-19 case shortly after the Cabinet met to approve a new nationwide lockdown.Agriculture Minister Charlie McConalogue confirmed Wednesday that he has tested positive for the virus and is self-isolating at home. The news means that the rest of Ireland’s 15-member Cabinet and other officials are being tested and are minimizing their own contacts pending their results. They all are presumed to have come into close contact with McConalogue during Tuesday’s three-hour Cabinet meeting at which the fresh lockdown was approved. It was held in Dublin Castle rather than in the much closer quarters of the Cabinet table in Prime Minister Micheál Martin’s office, in an attempt to reduce infection risk.
Harvard Medical School researchers have succeeded in developing a topical treatment that, in mice, wipes out herpes virus, one of the most intractable sexually transmitted human diseases. Judy Lieberman, professor of pediatrics and a senior investigator at the Immune Disease Institute, has overseen the development of the treatment that uses RNA interference, or RNAi, to disable key genes necessary for herpes virus transmission. That cripples the virus in a molecular two-punch knockout, simultaneously disabling its ability to replicate, as well as the host cell’s ability to take up the virus.What’s more, the treatment is just as effective when applied anywhere from one week prior to a few hours after exposure to the virus. In that sense, the basic biology of this prophylactic enables a real-world utility.“People have been trying to make a topical agent that can prevent transmission — a microbicide — for many years,” says Lieberman. “But one of the main obstacles for this is compliance. One of the attractive features of the compound we developed is that it creates in the tissue a state that’s resistant to infection, even if applied up to a week before sexual exposure. This aspect has a real practicality to it. If we can reproduce these results in people, this could have a powerful impact on preventing transmission.”These findings will be published in tomorrow’s edition of Cell Host & Microbe.The World Health Organization estimates that approximately 536 million people worldwide are infected with herpes simplex virus type 2 (HSV-2), the most common strain of this sexually transmitted disease. Women are disproportionately affected. This is especially serious, since the virus can easily be passed from mother to child during birth, and untreated infants face risks of brain damage and death. While HSV-2 alone isn’t life-threatening in adults, infection does increase a person’s vulnerability to other viruses such as HIV.In order for the herpes virus to infect the host, two conditions must be met. First, the virus must be able to enter and take over host cells. Second, the virus must then reproduce itself. Lieberman’s topical treatment uses RNAi to foil both these events.RNAi, a biological process that was identified barely a decade ago, has transformed the field of biological research. A breakthrough that earned the Nobel Prize in 2006, RNAi is a natural cellular process that occurs in all cells of all multicellular organisms to regulate the translation of genetic information into proteins. This natural process can be manipulated by researchers to switch off specific genes, and there is much current research and development work to harness RNAi for therapeutics.Many in the field think RNAi-based drugs may be the next important new class of drugs. By introducing tiny RNA molecules into cells, researchers can target a gene of interest and, in effect, throw a wrench into that gene’s ability to build protein molecules. For all intents and purposes, that gene is now disabled.While RNAi has profoundly accelerated the ability of scientists to probe and interrogate cells in the petri dish, therapeutic breakthroughs have proved far more problematic. Researchers have had a difficult time delivering these tiny RNA molecules and ensuring that they actually penetrate the desired cells and tissues in a living organism.Modifying a delivery technique that Lieberman developed in 2005, she and postdoctoral fellow Yichao Wu and junior researcher Deborah Palliser (who now heads her own laboratory at Albert Einstein College of Medicine) treated mice with strands of RNA that were fused to cholesterol molecules, which made it possible for the molecules to pass through the cell membranes. When applied in the form of a topical solution, these RNA molecules could then be fully absorbed into the vaginal tissue, protecting the mice against a lethal dose of administered virus.One RNA molecule in the topical solution targeted a herpes gene called UL29, which the virus needs to replicate. Knocking out UL29 inactivates the virus.Another RNA molecule targeted Nectin-1, a surface protein found on cells in the vaginal tissue. Nectin-1 acts as a kind of host gatekeeper to which the virus binds to pass into the cell. Without Nectin-1, the virus simply can’t infect cells.Either RNA molecule delivered by itself would be sufficient to block the virus, but together in this RNAi cocktail, the host tissue becomes like a fortress that pulls up the drawbridge to block the enemy’s entrance, and also has a full-fledged battle plan to slaughter the enemy if they make it through.“As far as we could tell, the treatment caused no adverse effects, such as inflammation or any kind of autoimmune response,” says Lieberman. “And while knocking out a host gene can certainly be risky, we didn’t see any indication that temporarily disabling Nectin-1 interfered with normal cellular function.”Lieberman was recently awarded a grant from the Massachusetts Life Science Center to collaborate with a corporate partner to build on these results to develop a topical microbicide that might be suitable for human use.In addition, she’s investigating how this same approach might be used to treat HIV in a multi-institutional program funded by the National Institutes of Health.
Continuing their 25th-anniversary celebration, The String Cheese Incident has announced a two-night Denver run over Thanksgiving weekend.On Friday, the band announced that they will offer up two performances at Denver, CO’s new Mission Ballroom, set for Friday and Saturday, November 29th and 30th.The band notes that the Mission Ballroom Incidents will be the final shows of 2019 as they’ll be focusing on songwriting through the early part of next year. SCI will be back on the road playing shows in June 2020.Next up for SCI is a three-night run at Eugene, OR’s Cuthbert Amphitheater on September 27th-29th. The band will then head to the Bay Area for a pair of two-night runs at San Francisco’s Fillmore (10/2 & 10/3) and Oakland’s Fox Theatre (10/4 & 10/5). Cheese will also offer up three-night runs at Austin, TX’s Stubb’s on October 31st-November 2nd and Chicago, IL’s Auditorium Theatre on November 7th-9th.Fans can now enter a ticket request here and ends on Monday, August 26th at 12 p.m. (MST).Tickets for The String Cheese Incident’s Mission Ballroom run go on sale to the general public beginning on Friday, August 30th at 10 a.m. (MST).For a full list of The String Cheese Incident’s upcoming tour dates, ticketing, and more information, head to the band’s website.
Sandra Okuboyejo(Photo provided by DKC/O&M) MCC Theater has announced complete casting for Nollywood Dreams, a new play by Jocelyn Bioh set to make its world premiere next month. The previously announced production, directed by Saheem Ali, will begin previews on March 19 and open on April 13 at the Robert W. Wilson MCC Theater Space.The cast will include Sandra Okuboyejo (Hamilton) as Ayamma, Charlie Hudson III (A Raisin in the Sun) as Gbenga, Ade Otukoya (Shades of Blue) as Wale Owusu, Emana Rachelle (Insecure) as Fayola, Zenzi Williams (Bioh’s School Girls; Or, the African Mean Girls Play) as Adenikeh and Lortel nominee Nana Mensah (Man From Nebraska) as Dede.Set in 1990s Lagos, Nigeria, where the Nollywood film industry is exploding and taking the world by storm, the play centers on Ayamma (Okuboyejo), who has dreams of stardom while working at her parents’ travel agency alongside her lovable and celebrity-obsessed sister Dede (Mensah). When Ayamma lands an audition for a new film by Nigeria’s hottest director Gbenga Ezie (Hudson), she comes head to head with Gbenga’s former leading lady, Fayola (Rachelle). Tensions flare just as sparks start flying between Ayamma, the aspiring ingénue, and Wale (Otukoya), Nollywood’s biggest heartthrob.Nollywood Dreams will feature scenic design by Arnulfo Maldonado, costume design by Dede Ayite, lighting design by David Weiner, sound design by Palmer Hefferan and projection design by Alex Basco Koch.The production is scheduled to play a limited run through April 26. Nollywood Dreams Related Shows View Comments
Related The Union Cycliste Internationale (UCI) has imposed a series of measures on the organisers of the BinckBank Tour in Belgium and The Netherlands, due to safety failings noted during the 2019 edition.UCI noted that the event, which took place between 10-18 August 2019, ‘provoked concerns among riders due to the dangerous nature of the course.’ The UCI and Cyclistes Professionnels Associés (CPA), the association representing riders, have held several discussions on how to improve the safety conditions of the event.Based on a report of the UCI Commissaires’ Panel, and having heard from the organisers, the UCI identified various situations constituting breaches of the UCI Regulations. These concerned event organisation and safety, and specifications for organisers. Due to these breaches, the Professional Cycling Council (PCC) made the following rulings:The presence in 2020 of a Technical Advisor, appointed by the UCI and at the cost of the organisers.The implementation of a plan of action devised by the UCI and approved by the Professional Cycling Council (PCC) in preparation for the 2020 BinckBank Tour.An evaluation of the standard of quality and safety of the organisation of the event, which will remain part of the UCI WorldTour Calendar in 2020. A decision regarding the status of the event will then be made based on that evaluation.In addition, a fine was imposed on the organisers as part of a procedure of acceptance of consequences.The UCI added that… ‘it would like to underline the spirit of collaboration demonstrated by the organisers during this procedure and their willingness to improve the safety conditions of their event in order to meet the regulatory safety requirements of an event on the UCI WorldTour, the leading series of men’s professional road cycling.’Since 2017, UCI regulations have been modified to allow the UCI to preside over race safety – firstly through new rules concerning drivers, which have made it possible to sanction several drivers for dangerous behaviour during races. Since 2019, a section specific to breaches on the part of organisers has enabled the UCI to make disciplinary rulings on, most notably, safety failings. This was invoked for the first time in the present case, and ‘other procedures are ongoing’.The possibility of imposing sanctions on organisers is part of a series of initiatives adopted by the UCI in recent years, in partnership with professional road cycling’s various stakeholders. In an ongoing effort to promote rider safety initiatives have included: the extreme weather protocol; the deployment of UCI Technical Advisors; guidelines for vehicle circulation in the race convoy; and a reduction in the number of riders in races.www.binckbanktour.comwww.uci.org