by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeDaily FunnyFemale Athlete Fails You Can’t Look Away FromDaily FunnyUndoNoteableyJulia Robert’s Daughter Turns 16 And Looks Just Like Her MomNoteableyUndozenherald.comDolly Finally Took Off Her Wig, Fans Gaspedzenherald.comUndoMisterStoryWoman files for divorce after seeing this photoMisterStoryUndoPast Factory4 Sisters Take The Same Picture For 40 Years. Don’t Cry When You See The Last One!Past FactoryUndobonvoyaged.comThese Celebs Are Complete Jerks In Real Life.bonvoyaged.comUndoBetterBe20 Stunning Female AthletesBetterBeUndoPost FunRare Photos Show Us Who Meghan Markle Really IsPost FunUndoautooverload.comDeclassified Vietnam War Photos The Public Wasn’t Meant To Seeautooverload.comUndo Yet she said initiatives such as Permanent Structured Co-operation, a drive for more military cooperation, should not be instead of Nato or against it. whatsapp whatsapp She said this was because “Europe currently cannot defend itself on its own”. Wednesday 27 November 2019 2:56 pm Read more: Donald Trump set to return to London for Nato meeting Macron said earlier this month that Nato was suffering “brain death” due to poor coordination and the volatility of US President Donald Trump. Share Earlier this month, in an interview with The Economist, Macron said the US was showing signs of “turning its back on us”. This morning, Merkel told the Bundestag – the German parliament – that “maintaining Nato today is even more in our very own interests as it was in the Cold War – or at least as important as it was in the Cold War”. Trump was accused of undermining Nato by harshly criticising Berlin’s approach to defence in a speech last year. More From Our Partners Biden received funds from top Russia lobbyist before Nord Stream 2 giveawaynypost.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.org‘Neighbor from hell’ faces new charges after scaring off home buyersnypost.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.com In her speech to lawmakers, Merkel today agreed with Macron’s assertion that Europe must cooperate better on defence, and praised progress made so far. Harry Robertson Trump is scheduled to come to London next month for the second time this year for a Nato summit on international security. Member states will be hoping he does not lambast his allies as he did in 2018. Angela Merkel says Europe cannot do without Nato Nato – the North Atlantic Treaty Organisation – is a defence pact between 29 states in North America and Europe. Among its key members are the US, the UK, France, Germany, Italy, and Turkey. German chancellor Angela Merkel appeared to rebuke French President Emmanual Macron today when she said Europe cannot defend itself without the Nato defence alliance. Angela Merkel’s Germany has drawn criticism from Washington over Nato (AFP via Getty Images) It has become the target of frequent attacks by Trump, however. He has expressed anger that many members states, particularly Germany, are not meeting a US-driven target to spend two per cent of GDP on defence.
whatsapp More than one in five (21%) B2C services firms were not able to offer any flexible working options at all, in comparison to just seven per cent of B2B service businesses. When asked what they considered to be a barrier to implementing remote working in their businesses, more than half (55%) of firms made reference to staff morale or mental health and wellbeing. Home working has been widely adopted during the pandemic and could be here to stay for many employees. Also Read: Home working widely adopted but concerns remain about morale Share Most businesses, particularly in the likes of finance and law, were able to offer remote working during the pandemic, however concerns about staff morale and mental wellbeing are still seen as a barrier to make the change permanent. There were also major sector differences when asked about barriers, with the likes of manufacturers citing the requirement for physical presence to operate equipment (53%), while in B2C service firms just 35 per cent made reference to physical presence required for their job role. Home working has been widely adopted during the pandemic and could be here to stay for many employees. Show Comments ▼ “But it’s clear that some firms and individuals are facing barriers to remote working with many employers concerned about the impact on team morale and employee wellbeing.” Around 80 per cent of B2B services firms like finance and law were able to offer working from home during the pandemic, while just 61 per cent of manufacturers and 54 per cent of B2C services companies like hospitality and retail were able to make the same offer. Sunday 30 May 2021 12:39 pm Home working has been widely adopted during the pandemic and could be here to stay for many employees. Also Read: Home working widely adopted but concerns remain about morale Home working has been widely adopted during the pandemic and could be here to stay for many employees. Also Read: Home working widely adopted but concerns remain about morale Home working widely adopted but concerns remain about morale Hannah Godfrey Some two-thirds (66%) of businesses surveyed by the British Chambers of Commerce (BCC) were offering remote working to employees. BCC head of people policy Jane Gratton said: “These results show that nearly three-quarters of firms will now continue to benefit from a remote working option during the coming year. Unsurprisingly there were major sector differences in the results. Tags: Company Nearly three-quarters of the businesses surveyed expect to have at least one employee working remotely over the coming year, with around half of companies expecting just over half of their employees to continue working remotely. More From Our Partners Brave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgWhy people are finding dryer sheets in their mailboxesnypost.comBiden received funds from top Russia lobbyist before Nord Stream 2 giveawaynypost.comKiller drone ‘hunted down a human target’ without being told tonypost.com‘Neighbor from hell’ faces new charges after scaring off home buyersnypost.com980-foot skyscraper sways in China, prompting panic and evacuationsnypost.comUK teen died on school trip after teachers allegedly refused her pleasnypost.comBill Gates reportedly hoped Jeffrey Epstein would help him win a Nobelnypost.comMatt Gaetz swindled by ‘malicious actors’ in $155K boat sale boondogglenypost.comConnecticut man dies after crashing Harley into live bearnypost.comInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse estatenypost.comSupermodel Anne Vyalitsyna claims income drop, pushes for child supportnypost.com In addition, 30 per cent pointed to fairness to staff whose role cannot be performed remotely. whatsapp
She explained to lawmakers how their information is important for drafting building codes, setting insurance rates, mapping tsunami evacuation zones, and for engineers as they design every piece of infrastructure or construction project in the state.In a phone interview later, Buurman explained how they have 150 seismic monitoring stations located in mostly remote areas around the state. The more stations that are placed around a fault line, the better the speed and accuracy in determining an earthquake’s location and magnitude.“There is a seismometer which we dig into the ground and is buried below ground,” Buurman said. “And then we usually have some sort of hut or structure that holds all the rest of the equipment, and that includes a large bank of batteries to keep the power running. There are solar panels on the side of the hut to keep the batteries charged, and radio communications equipment to transmit the data 24/7.”Buurman said about 40 of the 150 stations are currently offline.Some of the common malfunctions include wildlife getting into the huts and chewing on the cables and equipment. Snow can cover the solar panels, which can prevent station batteries from recharging. Part of the communications network can also break down and prevent data from being passed on from a group of nearby operating stations.Some of the bigger outages include the southern end of Kodiak Island and north of Yakutat.Buurman wrote to North Pole Rep. Tammie Wilson that it took 30 minutes to update state emergency officials after Monday’s earthquakes. She writes that the national standard is 10 minutes.State seismologist Michael West said the Alaska Earthquake Center gets almost a third of its $2.5 million funding from the state, a third from the federal government, and a third from private corporations for specific projects like monitoring a hydroelectric dam or the trans-Alaska Pipeline.West said state dollars actually serve as seed funding that leverage federal dollars, which have also been declining. He said only $588,000 may be appropriated by state lawmakers this year, down from $800,000 before 2014.Both the House and Senate have passed their own versions of the state operating budget, but the Senate has delayed negotiations over resolving differences in the bill.West is hopeful that Alaska’s Congressional delegation will be able to appropriate additional federal funds.Share this story: Public Safety | Science & Tech | State Government | University of AlaskaYears of budget cuts hamper monitoring of Alaska earthquakes, including Monday’sMay 3, 2017 by Matt Miller, KTOO Share:Field engineer Scott Dalton adjusts a radio communications link at a seismic station south of Cantwell. (Photo by Ian Dickson/Alaska Earthquake Center)Technicians service a remote seismic station in the Wrangell-St.Elias region. (Photo by Dara Merz/Alaska Earthquake Center)12
In a further sign that the worst of the recession is behind us, the world’s largest automotive markets are all showing high growth rates, with sales of light goods vehicles and automobiles almost back to pre-crisis levels.The world’s three largest markets – the US, Europe and China – have all seen sustained growth return over the past few months as consumers have returned to buying patterns last seen before the 2008 recession.In what is probably the most significant sign of sales growth, given its recent economic travails, is the double-digit increases seen in Europe for in March, which saw passenger car registrations up 10.6%, according to the European Automobile Manufacturers Association.Registrations for the first quarter were up 8.4% year-on-year, with all of the major individual markets showing good growth: 2.9% in France, 5.6% in Germany, 5.8% in Italy, 11.8% in Spain and 13.7% in the UK.The UK has now seen 26 months of consecutive growth in sales, and the Society of Motor Manufacturers and Traders expects the UK automotive industry to be turning out more than two million units a year by 2017, beating the previous annual record of 1.92m units, in 1972.In the US, car sales were up 9.1% year on year in April – the best April for automobile sales since 2006 – while in China, March sales of passenger cars were up 7.9% year on year, and first-quarter sales were up 10.1% on 2013.The growth is also being felt by the logistics operators that serve the automotive market, said DSV’s sector development manager Arcadio Martinez.“We are now at the levels that we last saw in 2008 and 2007, helped by manufacturers developing new models and new products – there is growth in the US and Europe, and China has become one of the most important markets in the world.”However, he added that this growth had been accompanied by a rapid increase in the complexity of the automotive supply chain.“One of the trends that we have seen is that there are a lot more electronic components being used in cars and as these parts are more expensive than they were before the cost of inventory to the OEMs and their tier one suppliers is more important than before.”As a result, he said, automotive shippers wanted faster transit times as the supply chain “has become part of the manufacturing process”.“The lead times are key, as well as the quality of services in terms of reliability and visibility, and to fulfil these requirements you need, for example, a road network with a certain level of density,” he told The Loadstar at last week’s Multimodal show in Birmingham.The increasing cost of inventory and the spread of automotive manufacturing production across the world had led manufacturers to demand faster transit times across larger distances, said Neil Williams, group managing director of express provider Priority Freight, which focuses on serving the automotive sector, as well as aviation spare parts and the pharma industry.“We are in a sector where the expedited demands of our clients are becoming much more global – competition between logistics providers in Europe is now very focused, and the market is moving to a level of maturity that is comparable with the US.“Now, manufacturers are expecting that kind of level of service on a global basis,” he said, adding that as a result the company was looking to expand its global footprint over the next five years.It has targeted five key markets – China, the US, India, Brazil and Mexico – where it is looking to develop an on-the-ground presence, “either through acquisition of joint-venture”, as it follows the migration of its customers.The company has been positioning itself as a lead logistics provider for expedited freight services – it coined the term expedited contingency logistics – in the belief that, given the costs of inventory and working capital, it is cost-effective for large-scale carmakers to use express services as a part of planned supply chain.However, while major markets appear to have returned to a period of sustained growth, other markets that seemed to promise rapid growth have failed to materialise, said Mr Martinez.“China apart, the demand from the other BRIC countries – Brazil, Russia and India – has not really lived up to its promise,” he said. By The Loadstar in Birmingham 08/05/2014
By Ed Silverman March 30, 2017 Reprints Log In | Learn More About the Author Reprints What’s included? Pharmalot GET STARTED What is it? [email protected] A Nevada lawmaker has introduced a bill to fight the rising cost of medicines, one of dozens state legislators to attempt such a move. But this one has a twist — the legislation targets only companies that make diabetes drugs and insulin.Specifically, the bill requires drug makers to report pricing histories; disclose a slew of costs, such as research, manufacturing, and patient assistance; and notify state officials and insurers at least 90 days before prices are increased above the inflation rate for the preceding year. Unlock this article — plus daily coverage and analysis of the pharma industry — by subscribing to STAT+. First 30 days free. GET STARTED Tags drug pricingpharmaceuticalsSTAT+ @Pharmalot STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. Ed Silverman Pharmalot Columnist, Senior Writer Ed covers the pharmaceutical industry. A Nevada bill targets drug makers over price hikes, but only for diabetes meds Insulin bottles at a Novo Nordisk factory in France. Francois Monier/AFP/Getty Images Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr.
In addition to the monetary penalties, the order also prohibits Mallett from soliciting money for any investment-related activity until 2015. After that, he can apply to be registered as a salesperson in the investment industry. The settlement approved by a panel of the NBSC earlier this month. “We expect that individuals who speak to our investigators be truthful in the information they provide,” said Rick Hancox, executive director of the NBSC. “Interviewing witnesses is one of the primary tools that our enforcement team has to detect and prevent improper investment practises.” The New Brunswick Securities Commission (NBSC) has sanctioned a man for misleading one of its investigators. The regulator announced today that a businessman, Wayne Mallett, was ordered to pay $15,000 in administrative penalties and $2,000 in costs as part of a settlement agreement, in which he agreed that he made misrepresentations to an NBSC investigator during a compelled interview. During that interview, he denied having a working relationship with a particular company that was selling investments in New Brunswick when, in fact, he was working on behalf of the company. PwC alleges deleted emails, unusual transactions in Bridging Finance case James Langton BFI investors plead for firm’s sale Mouth mechanic turned market manipulator Keywords EnforcementCompanies New Brunswick Securities Commission Share this article and your comments with peers on social media Related news Facebook LinkedIn Twitter
RelatedJamaica Celebrates National Minerals Week, February 15-21 Advertisements RelatedArchives Critical to Jamaica’s History RelatedJamaica Celebrates National Minerals Week, February 15-21 FacebookTwitterWhatsAppEmail The Ministry of Mining and Telecommunications has organised a number of activities in observance of National Minerals Week in Jamaica, February 15-21.These activities will be held in keeping with the theme for the week, ‘Modernising the Minerals Industry Meeting the Global Challenge.’ Highlights include a ceremonial launch at the Jamaica Conference Centre, by Minister of Mining & Telecommunications, Derrick Smith.Speaking at the JIS ‘Think Tank’ yesterday (February 5), Senior Director of Policy Planning & Development in the Ministry of Mining and Telecommunications, Oral Rainford, rationalised the week’s activities.“The official opening,” he said, “will be part of a seminar on equipment management in minerals operations, intended to offer professional guidance on the effective management of heavy equipment.”The seminar will offer valuable information for mining and other operations, including construction, engineering and agribusiness, as well as the operation of conveyor belt systems.Mr. Rainford said the seminar presenters would include experts from Caterpillar International, as most heavy equipment used in Jamaica is supplied by Caterpillar.Another of the week’s activities involves discussions led by minerals consultant, Norman Davis, and Jamaica Bauxite Institute board member, Dennis Morrison. They will share with participants, investment opportunities in industrial mining. These will include mining of limestone, shale, gypsum and pozzolon (a volcanic-type building material), some of which are used in construction, manufacture of cement and in road building.Mr. Rainford explained that there was a great demand for these materials both locally and overseas, but Jamaica was producing below capacity.National Minerals Week ends with a trade show and exhibition at the Jamaica Conference Centre. This event will be free of cost to the public and should appeal to students, shoppers, business people and the entire family.Other activities include, public discussions and field trips to sites and quarries, which are free of cost.Mr. Rainford said the Ministry staged a successful week of activities, last year, to raise awareness about the potential of minerals and their value-added products as viable investment opportunities. They expect that Minerals Week 2009 will build on this.Persons should contact the Ministry of Mining and Telecommunications for further details. More information will be made available in the press. Jamaica Celebrates National Minerals Week, February 15-21 InformationFebruary 7, 2009
Consumer input into medicine and device approval processes urgently needed PainaustraliaPainaustralia has today called for meaningful and greater input for consumers as part of the approval processes for new devices and medicines in Australia.Appearing at the House of Representatives Standing Committee on Health, Aged Care and Sport – Approval processes for new drugs and novel medical technologies in Australia, Painaustralia CEO Carol Bennett said there must be a better way to consult consumers throughout the regulatory process as the current processes are leaving consumers disappointed and bereft of hope.“Consumer input needs to be considered, valued and adopted when making decisions that have a real impact on the quality of life of those living with pain and other health conditions,” she said.Ms Bennett said the recent changes to opioid regulation and the decision of the PBAC to restrict access to opioids for chronic pain at short notice and without alternative treatments and appropriate information for clinicians and consumers in place had been extremely difficult for many people.“It goes to the heart of the context in which these decisions are taken. While it may be important to restrict opioids in order to manage increasing levels of harm, this decision has had an enormous impact on people who have relied on opioids for managing chronic pain (often for many years) in the absence of other accessible and affordable treatments. It’s no wonder this has led to significant distress and in many instances, suicidal intentions.“The limited timeframe, quick turnaround and lack of transparency around decisions when consumers are consulted highlights the weaknesses in the current system.”Ms Bennett said listening to consumers and gaining insight into how best to develop policy and practice goes well beyond consumer representation on decision-making bodies or ad hoc consultation.“The tick-the-box approach to consumer consultation, compounded by limited timeframes, minimal ongoing engagement and limited response options are just some of the current weaknesses of what is called consumer consultation,” she said.“Unless we provide consumers with access to affordable, best practice alternatives, medicines will continue to play an important role in chronic pain management. That means we need systematic and genuine consultation with consumers who will be most impacted by these decisions.”Painaustralia has also called on the Australian Government to reinstate the review of the National Medicines Policy which has been put on hold due to the pandemic, with a brief to include diverse consumers and key stakeholders in the consultation process. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:aged care, Australia, Australian, Australian Government, chronic, chronic pain, device, Government, health, Impact, medicine, opioids, pain management, pandemic, quality, regulation
Major Mascot station upgrade underway Construction is underway on the $39 million makeover of Mascot Station, which will reduce crowding for train commuters and congestion for road users.Minister for Transport and Roads Andrew Constance said the upgrade includes a brand new entrance/exit on the western side of Bourke Street, additional ticket gates, new escalators and a lift to the paid concourse area.“We’re pressing ahead with this important upgrade to ensure this busy transport hub can meet the needs of our customers now and into the future,” Mr Constance said.“Not only will it make life easier for train customers, but road users will also notice reduced congestion on Bourke Street with less people having to rely on the pedestrian crossing to access the station.”Transport for NSW Chief Operations Officer Howard Collins said there will be some changes to traffic and pedestrian access in and around the station as a result of the work.“As with any major project, there will be disruption to the local community but we will be doing everything we can to reduce the impacts as much as possible,” Mr Collins said.“Transport for NSW will keep the community and commuters informed, and continue to work with affected residents and businesses to support them during this time.”The Mascot Station upgrade is part of the NSW Government’s $5.3 billion More Trains, More Services Program, and is expected to be completed by late 2022.The program is also delivering a new substation at Mascot (which was announced in May last year) to improve rail services for T8 Airport Line customers.The program is aiming to increase services for Mascot customers during the morning peak by 80 per cent, meaning there will be trains every three to four minutes instead of every six. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:airport, Bourke, community, future, Government, Howard, Liberal Party, Mascot, meet, Minister, NSW, nswpol, Pedestrian, project, Transport
COVID-19 digital certificates now available Every Australian, including dentists for whom the ADA advocated to be included in the first round of vaccinations, who has received all of their required COVID-19 vaccine doses is now able to access the recently launched COVID-19 digital certificate.The Minister for Government Services, Senator the Hon Linda Reynolds CSC, said the new record makes it simple and easy for people to show their COVID-19 vaccination status.“The COVID-19 digital certificate makes proof of vaccination accessible anytime, anywhere,” Minister Reynolds said.“We’re also giving people control over the level of vaccination history they share, as the certificate only shows your COVID-19 vaccination status. Once your provider has reported both doses of an approved vaccine, you’ll be able to access your COVID-19 digital certificate online through myGov or in the Express Plus Medicare app. I’m encouraging all Australians to ensure you’ve linked your Medicare account to myGov.” /ADA Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Australia, Australian, Australian Dental Association, covid-19, dental health, dental industry, digital, Government, Internet, Medicare, Minister, online, vaccination, vaccinations, vaccine